Quality columns you can rely on for quality results
Need a reliable column? With over 40 years as a leader in LC column technology, you can rely on the quality of Thermo Scientific™ HPLC and UHPLC columns. Our extensive family of products offers a variety of particle sizes and column designs to meet all separation needs, including improved resolution, enhanced sensitivity, faster analysis and consistent performance.

Popular HPLC and UHPLC columns


Accucore Biphenyl Reversed Phase LC Columns   Accucore Vanquish C18+ UHPLC Columns, 1.5µm   ProPac Elite WCX LC Columns
Choose Thermo Scientific™ Accucore™ Biphenyl LC Columns for fast and reliable separation of critical pairs and isomers. These columns provide unique selectivity for aromatic and moderately polar analytes. Their optimized packing offers a rugged platform for a variety of matrices. Based on Core Enhanced Technology, Accucore liquid chromatography reversed phase columns provide fast, high-resolution separations without the elevated backpressures seen using sub-2µm particles.   Choose Thermo Scientific™ Accucore™ Vanquish™ C18+ UHPLC columns, containing uniquely efficient 1.5 µm solid core particles for use with the Thermo Scientific™ Vanquish™ UHPLC system. Founded on state-of-the-art Core Enhanced Technology™, this sub-2 μm particle next-generation column has ultra-short diffusion paths that result in extremely efficient separations. This high efficiency enables fast separation and the resolution of complex mixtures. In concert with Vanquish systems, these columns deliver more results with better separations, thereby enhancing workflows and productivity.   Discover the unique Thermo Scientific™ ProPac™ Elite WCX weak cation exchange (WCX) liquid chromatography column. Designed for protein characterization including therapeutic proteins, monoclonal antibodies (mAbs), antibody drug conjugates (ADCs) and biosimilar proteins, this column offers high resolution, high efficiency separation of proteins and their charge variants. The unique column chemistry provides excellent performance under a broad range of pH, temperature and mobile phase compositions with excellent recovery and low carryover.

HPLC and UHPLC column categories


Bio LC Columns   Reversed Phase (RP) HPLC Columns   Normal Phase HPLC Columns   HILIC HPLC Columns
Have a biological sample? Get high resolution, high efficiency separations from our unique chemistries that are specially designed for proteins, peptides, carbohydrates, nucleic acids, oligonucleotides and more.   Need to maximize your productivity and flexibility in method development? We offer an array of RP chemistries to optimize separations and provide enhanced retention or changes in elution order.   Is your sample insoluble in mixtures of water and organic solvent? We manufacture a range of bonded and non-bonded normal phase columns that are ideal for the retention and separation of lipophilic compounds.   Have difficulty retaining polar hydrophilic compounds by RP chromatography? These columns strongly retain compounds that are unretained by conventional reversed phase, without the need for ion-pair additives.
Amide HILIC HPLC Columns   Mixed-Mode HPLC Columns   Ion Exchange HPLC Columns   Ligand Exchange HPLC Columns
Need a HILIC column for very polar analytes? These columns are well suited for separating hydrophilic molecules, including carbohydrates, glycans, and peptides.   Want to separate ionic and hydrophobic analytes in a single run? The multi-functionality of these columns can eliminate column switching, ion paring, or using columns in series.   Are your analytes ionizable or charged in solution? Our silica-based ion exchange columns are ideal for smaller water-soluble compounds.   Need a column to separate carbohydrates using dilute acid mobile phase? These polymeric ligand exchange columns utilize a range of counter ions to deliver selectivity required.
  Size Exclusion HPLC Columns   Application Specific HPLC Columns  
  Want high resolution separation of water-soluble polymers? Our size exclusion columns (SEC) are available in tailored pore sizes to cover a broad range of molecular weight.   Designed for key pharmaceutical and environmental applications, these columns utilize novel and unique chemistries to provide superior resolution with ease of use.